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"We can say it is related to heightened

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risk. It found that people with atrial fibrillation, in which the upper chambers of the heart can quiver uselessly rather than pumping blood, were 44% more likely to develop dementia over a five-year period
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than those without the heart disorder. "Finally, multiple
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studies show the presence of sub-clinical strokes in atrial fibrillation and dementia," Bunch said.

"We have done it with 2,000 patients, and we are following these patients." 2009. All of those

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preventive treatments would have to be started early, he said. Those with atrial fibrillation were
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130% more likely to develop Alzheimer's disease. And the combination could be lethal. One aggressive therapy is catheter ablation, in which a catheter is threaded into the heart to cauterize the area where atrial fibrillation originates, he said. Treatment with statins, which have anti-inflammatory properties, or medications aimed directly at inflammation, could thus be used. Creighton Day, director of heart rhythm services at Intermountain,
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and a member of the research team.

Some 2 million teens in the United States have had a bout of MDD in the past year, the company said. News Articles

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Next Article. Earlier studies have shown that people with atrial fibrillation are at higher risk of some forms of dementia, Bunch said. The clot-preventing drug Coumadin now is often prescribed for people with atrial fibrillation, because the condition heightens the risk of clot formation.

"We can't

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say yet that it is causal," Bunch said of the relationship. "Unfortunately, for this condition, it takes a number of years to see if it makes a difference," Day said. Forest has
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denied the complaint's allegations, the wire service said. Biomarkers May Predict Alzheimer's Printer-Friendly
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His group was to present the finding in Boston at the Heart Rhythm Society's annual meeting. The association was especially strong for people under the age of 70. Dewey Bunch, an electrophysiologist

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at Intermountain Healthcare in Salt Lake City. "Many small strokes over time can cause the damage." If that theory proves out, the treatment would be aimed at preventing the blood clots that caused such small strokes, he said. It is also possible that inflammation is the underlying problem in both conditions, he said, since
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indicators of increased inflammation, such as the molecule C-reactive
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protein, have been found in both cases. Omega-3 Fatty Acids Might Curb Depression Printer-Friendly Format Email to a Friend Latest Alzheimers News Biomarkers May Predict Alzheimer's Naproxen May Help Prevent Alzheimer's New Treatments
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Approved for adults in 2002, Lexapro is among a class of antidepressants called selective serotonin reuptake inhibitors (SSRIs). Sign Up for MedicineNet Newsletters. Gilbert and intensive treatment of high blood pressure

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thus might prevent dementia, Bunch said. News Articles
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Next Article. Lexapro and similar antidepressants include an FDA "black-box" label warning stating they show an increased risk compared to a non-medicinal placebo of "suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD)
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and other psychiatric disorders." The
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warning advises that anyone considering the use of Lexapro or any other antidepressant in a child, adolescent, or young adult "must balance this risk with the clinical need." 2009. The study found that people with atrial fibrillation and dementia were 61% more likely
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to die during the five-year study period.

"We should have a pretty good idea over the next few years whether this works out," Day said. "We're going to begin looking at 50-year-olds," Bunch said. Justice Department last month filed a complaint against Forest, alleging that the drug maker had inappropriately promoted Lexapro for use by children. But this was the first large-scale

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population study to show an association of atrial fibrillation and increased risk of developing Alzheimer's disease, he said.

There are three possible explanations for the relationship, each of which could lead to prinz treatment aimed at preventing the dementia, said study T. The study used data on 37,000 people treated at the 20 hospitals run by Intermountain Healthcare in Utah, Idaho and Wyoming. It was evaluated in treating adolescent depression in two placebo-controlled studies, the news release said. Other clot-preventing measures could also be used, Bunch said. One question is whether truly aggressive therapy for atrial fibrillation is warranted, said Dr. The next step is to look at the mechanistic association, to understand how one predisposes to the other." One possibility, he said, is that both problems are related to high blood pressure, which could cause heart function to deteriorate so that blood flow to the brain is reduced, starving brain cells of oxygen.

   














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